Author/Editor		Pajek, Jernej
Title		Kardiorenalni sindrom: definicija, klasifikacija ter novejši rezultati raziskav patogeneze
Translated title		Cardiorenal syndrome: definition, classifikaction and recent results of studies on pathogenesis
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 79, št. 6
Publication year		2010
Volume		str. 488-98
Language		slo
Abstract		Background: The term cardiorenal syndrome (CRS) has been used without a consistent definition. Since there is a high clinical impact of heart and kidney disease interactions a unified definition of CRS is warranted. Methods: CRS definition and classification proposal by an international group of authors in 2008 is presented. Medline and Index Medicus databases were searched for relevant articles and a current view on the pathogenesis of CRS subtypes as defined in this proposal is given. Results: CRS is defined as a pathophysiologic disorder of the heart and kidneys, whereby acute or chronic dysfunction of one organ induces acute or chronic dysfunction of the other. CRS is divided into 5 subtypes according to the primary failing organ and the time frame of dysfunction. With the CRS type 1 and 2, there are acute and chronic cardiac disorders causing renal injury with hemodynamic disturbances of renal perfusion, especially renal venous congestion being implicated as a major cause. The CRS type 3 and 4 may also be designated as renocardiac syndromes, as there are acute and chronic kidney diseases leading to cardiac dysfunction. Particularly type 4 CRS encompasses numerous hemodynamic, metabolic and neurohumoral derangements. CRS type 5 reflects a systemic condition causing both cardiac and kidney dysfunction. Conclusions: Unified definition and classification of CRS allows a more comprehensive understanding of complex heart and kidney disease interactions and it is a good platform for future research.
Descriptors		HEART FAILURE, CONGESTIVE KIDNEY FAILURE GLOMERULAR FILTRATION RATE CENTRAL VENOUS PRESSURE RISK FACTORS