Author/Editor		Stokin, Gorazd B; Goldstein, Lawrence SB
Title		Linking molecular motors to Alzheimer's disease
Type		članek
Source		J Physiol Paris
Vol. and No.		Letnik 99, št. 2-3
Publication year		2006
Volume		str. 193-200
Language		eng
Abstract		It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-beta peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.
Descriptors		AMYLOID BETA-PROTEIN PRECURSOR ANIMALS AXONAL TRANSPORT AXONS MODELS, BIOLOGICAL