Author/Editor		Rajter, M; Marolt-Gomišček, M; Jokovič, Ž
Title		Use of acute-phase proteins in differentiating viral from bacterial infections
Translated title		Reaktanti zgodnje faze vnetja v diferencialni diagnostiki med bakterijsko in virusno okužbo
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. 2
Publication year		1994
Volume		str. 57-60
Language		eng
Abstract		Background. The aim of our study was to determine the role of acute phase reactants in differentiating viral from bacterial infections. We wanted to find out which of six acute phase reactants (orosomucoid, haptoglobin, alpha-1-antitrypsin, C-reactive protein, ceruloplasmin and fibrinogen) is most suitable for a routine clinical use. Methods. The six acute phase reactants were determined by fixed-time immuno-chemical precipitation nephelometry in 31 patients with viral infections and 30 patients with bacterial infections, on the first day, 7th day and between 14th and 21st day after the admittance to the hospital. Results and conclusions. Fibrinogen and C-reactive protein proved to be the most sensitive indicators of bacterial infection. Since C-reactive protein has a shorter response time and its concentration in patients with bacterial infections is very high, it is probably more suitable for routine clinical use than the fibrinogen.
Descriptors		VIRUS DISEASES BACTERIAL INFECTIONS ACUTE PHASE PROTEINS DIAGNOSIS, DIFFERENTIAL NEPHELOMETRY AND TURBIDIMETRY FIBRINOGEN OROSOMUCOID ALPHA 1-ANTITRYPSIN HAPTOGLOBINS CERULOPLASMIN C-REACTIVE PROTEIN