Author/Editor		Miljković, Jovan
Title		Pojavi na koži pri levkocitoklastičnem vaskulitisu
Translated title		Clinical manifestations of cutaneous leukocytoclastic vasculitis
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 19, št. Suppl 1
Publication year		2010
Volume		str. 55-7
Language		slo
Abstract		Leukocytoclastic vasculitis is a histopathological term used to describe an inflammation of the blood vessels characterized by the presence of endothelialcell swelling, transmural neutrophilic inflammation with leukocytoclasia, fibrinoid necrosis of the vessel wall, and extravasation of red blood cells. Cutaneous leukocytoclastic vasculitis is the most common type of vasculitis that may be caused by numerous conditions. Despite the best diagnostic procedures, in approximately 50% of all cases the etiology remains unknown. The most common cutaneous manifestation of leukocytoclastic vasculitis is represented by purpura, but later skin lesions become papular, urticarial, papulo-nodular, targetoid, vesicular, pustular, or ulcerated. All these clinical manifestations of cutaneous leukocytoclastic vasculitis are similar in numerous clinical entities due to varied pathogenic mechanisms. For this reason, the histopathological term leukocytoclastic vasculitis should not be used as clinical diagnosis.
Summary		Levkocitoklastični vaskulitis je histopatološki pojem, s katerim opisujemo vnetni proces na žilah, za katerega so značilni: okvara žilne stene s fibrinoidno nekrozo, polimorfonuklearni vnetni infiltrat, v katerem je posebej značilen jedrni drobir (levkocitoklazija), in ekstravazacija eritrocitov. Kožni levkocitoklastični vaskulitis je najpogostejša oblika vaskulitisa, katerega vzrok so lahko številni dejavniki. V približno polovici primerov ostane vzrok nepojasnjen. Najbolj pogosta kožna sprememba pri kožnem levkocitoklastičnem vaskulitisu je purpura, druge kožne manifestacije se lahko kažejo kot papule, urtike, vozliči, kokarde, mehurji, pustule in/ali razjede. Kožne spremembe pri levkocitoklastičnem vaskulitisu so enake kot pri drugih kliničnih entitetah, ki se od levkocitoklastičnega vaskulitisa razlikujejo etiološko. Zaradi teh razlogov je uporaba pojma levkocitoklastični vaskulitis za klinično diagnozo neprimerna.
Descriptors		SKIN MANIFESTATIONS