Author/Editor		Čižman, M
Title		Klinična uporaba kombinacije antibiotikov
Translated title		Clinical use of antibiotic combinations
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. 4
Publication year		1994
Volume		str. 221-6
Language		slo
Abstract		Background. The article focuses on those combinations that are of clinical use. Conclusions. Combinations of antimicrobial agents are commonly used, most often in immunocompromised and in intensive care unit patients. It seems likely, however that the combination therapy is employed more frequently than warranted. The most prominent reasons are to increase the antimicrobial spectrum, to treat polymicrobial infections, to enhance killing or inhibition (synergism), to reduce the potential for developing resistance and less commonly to decrease the dosage of potentially toxic antibiotics. However antibiotic combinations can result in antagonismus, increased side effects, costs and other undesirable effects.
Descriptors		BACTERIAL INFECTIONS ANTIBIOTICS, COMBINED DRUG THERAPY, COMBINATION DRUG SYNERGISM DRUG ANTAGONISM DRUG INTERACTIONS