| Author/Editor | Barlič, Ariana; Božikov, Krešimir | |
| Title | Matične celice iz maščobnega tkiva in njihova uporaba | |
| Translated title | Stem cells from adipose tissue and their use | |
| Type | članek | |
| Source | Farm Vestn | |
| Vol. and No. | Letnik 61, št. 1 | |
| Publication year | 2010 | |
| Volume | str. 42-5 | |
| Language | slo | |
| Abstract | Subcutaneous adipose tissue represents an attractive source of progenitor cells due to its easy availability, abundance and the ability of self-renewal. It originates from mesodermal cell layer and contains stromal-vascular cell fraction (SVF), which can be easily isolated. This heterogeneous population of cells contains endothelial cells, smooth-muscle cells, pericytes, leukocytes, pre-adipocytes, and a population of multipotent mesenchymal stem cells, named adipose-derived stem cells (ASC). ASC have the ability to differentiate into cells of mesodermal origin - adipocytes, osteoblasts, chondrocytes and myocytes. Because of their high proliferative rate and differentiation capability in in vitro conditions, interest for their use in medicine is increasing rapidly. Adipogenic potential may have many uses in soft-tissue reconstruction. Their osteogenic potential could aid repair bone non-union fractures. If successful chondrogenesis could be achieved, ASC could be used to treat cartilage lesions and arthritic joints. According to recent investigations ASC possess immunosuppressive characteristics. Therefore, different autoimmune diseases could be treated. However, despite the initial enthusiasm over their use for clinical purposes, many scientific and medical issues still need to be resolved. In this review we summarize the latest findings about ASC and examples of their clinical use. | |
| Summary | Podkožno maščobno tkivo predstavlja privlaoeen vir predniških celic predvsem zaradi svoje lahke dostopnosti, obilnosti in sposobnosti samoobnavljanja. Izvira iz mezodermalne klične linije in vsebuje stromalno vaskularno frakcijo (SVF - Stromal Vascular Fraction) celic, ki jo zlahka izoliramo. Ta heterogena populacija celic vsebuje poleg endotelijskih celic, gladko-mišičnih celic, pericitov, levkocitov in preadipocitov, tudi populacijo multipotentnih mezenhimskih matičnih celic imenovanih matične celice iz maščobnega tkiva (ASC - Adipose-derived Stem Cells). ASC imajo sposobnost diferenciacije v celične linije mezodermalnega izvora t.j. v adipocite, osteoblaste, hondrocite in miocite. Interes za uporabo ASC v medicini strmo narašča zaradi njihove sposobnosti razmnoževanja in diferenciacije v in vitro pogojih. Adipogen potencial ASC bi lahko izkoristili za rekonstrukcije mehkih tkiv. Osteogen potencial bi lahko izkoristili pri težko celečih se zlomih kosti. Z uspešno hondrogeno diferenciacijo bi lahko z ASC zdravili poškodb hrustanca in artritis. Raziskave kažejo, da delujejo tudi imunosupresivno, kar bi lahko izrabili za zdravljenje različnih avtoimunskih bolezni. Kljub velikemu potencialu za uporabo ASC v klinične namene se je potrebno zavedati, da ostaja odprtih še veliko pomembnih znanstvenih in medicinskih vprašanj. V preglednem prispevku podajamo najnovejša dognanja na področju ASC in primere njihove uporabe v kliniki. | |
| Descriptors | ADIPOSE TISSUE STEM CELLS CELL DIFFERENTIATION SURGERY, PLASTIC |