| Author/Editor | Bergenstal, Richard M; Tamborlane, William V; Ahmann, Andrew; Battelino, Tadej | |
| Title | Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes | |
| Type | članek | |
| Source | N Engl J Med | |
| Vol. and No. | Letnik 363, št. 4 | |
| Publication year | 2010 | |
| Volume | str. 311-20 | |
| Language | eng | |
| Abstract | Background: Recently developed technologies for the treatment of type 1 diabetes mellitus include a variety of pumps and pumps with glucose sensors. Methods: In this 1-year, multicenter, randomized, controlled trial, we compared the efficacy of sensor-augmented pump therapy (pump therapy) with that of a regimen of multiple daily insulin injections (injection therapy) in 485 patients (329 adults and 156 children) with inadequately controlled type 1 diabetes. Patients received recombinant insulin analogues and were supervised by expert clinical teams. The primary end point was the change from the baseline glycated hemoglobin level. Results: At 1 year, the baseline mean glycated hemoglobin level (8.3% in the two study groups) had decreased to 7.5% in the pump-therapy group, as compared with 8.1% in the injection-therapy group (P<0.001). The proportion of patients who reached the glycated hemoglobin target (<7%) was greater in the pump-therapy group than in the injection-therapy group. The rate of severe hypoglycemia in the pump-therapy group (13.31 cases per 100 person-years) did not differ significantly from that in the injection-therapy group (13.48 per 100 person-years, P=0.58). There was no significant weight gain in either group. Conclusion: In both adults and children with inadequately controlled type 1 diabetes, sensor-augmented pump therapy resulted in significant improvement in glycated hemoglobin levels, as compared with injection therapy. A significantly greater proportion of both adults and children in the pump-therapy group than in the injection-therapy group reached the target glycated hemoglobin level. (Funded by Medtronic and others; ClinicalTrials.gov number, NCT00417989.) | |
| Descriptors | INSULIN INFUSION SYSTEMS ADULT ANALYSIS OF VARIANCE CHILD DIABETIC KETOACIDOSIS HEMOGLOBIN A, GLYCOSYLATED HYPOGLYCEMIA INJECTIONS, SUBCUTANEOUS INSULIN MONITORING, AMBULATORY TREATMENT OUTCOME |