Author/Editor		Vranac, Tanja; Bresjanac, Mara
Title		Metabolic aspects of prion diseases: an overview
Type		članek
Source		Curr Drug Targets
Vol. and No.		Letnik 11, št. 10
Publication year		2010
Volume		str. 1207-17
Language		eng
Abstract		Prion diseases are fatal neurodegenerative disorders that affect humans and other mammals. The hallmark of these diseases is the conformational change of the cellular prion protein (PrP(C)) to the misfolded protein capable of propagation and associated with neurodegenration, named prion (PrP(Sc)). In a strict sense, prion diseases are a consequence of aberrations in the metabolism of the cellular prion protein (PrP(C)). This brief review addresses current understanding of metabolic disturbances in prion disorders at the cellular, organ and organism level, selectively pointing out some relevant diagnostic and treatment options.
Descriptors		PRION DISEASES PRIONS PRPC PROTEINS PRPSC PROTEINS NERVE DEGENERATION TRANSLATION, GENETIC BRAIN NUCLEAR MAGNETIC RESONANCE TOMOGRAPHY, EMISSION-COMPUTED