Author/Editor     Takač, I; Vlaisavljević, V
Title     Preprečevanje pooperativnih zarastlin po mikrokirurški operaciji
Translated title     Prevention of postoperative adhesion formation after microsurgical operation
Type     članek
Source     Zdrav Vestn
Vol. and No.     Letnik 63, št. 6-7
Publication year     1994
Volume     str. 365-7
Language     slo
Abstract     Background. The efficacy of normal saline and hydrocortisone in the prevention of postoperative adhesions was examined. Methods. The uterine horns of 30 rats were subjected to both division and microsurgical anastomosis of proximal segment and bipolar electrocoagulation of the distal segment. They were randomly divided into three equal groups: first group received normal saline perioperatively, second group received hydrocortisone in normal saline perioperatively and hydrocortisone postoperatively and third group was a control without medication. At repeat laparotomy 2 weeks later the intraperitoneal adhesions were graded from 0 to 3 according to their severity. Separate adhesions scores were assigned to the areas of anastomosis and electrocoagulation. Results. Total adhesion scores were 71 for control group. 64 for normal saline group and 52 for hydrocortisone group. The hydrocortisone group formed significantly fewer adhesions than control group (p less th. 0.05). Althrough the normal saline treated rats had less adhesions than the controls, the difference was not significant. Conclusions. These results suggest that in this species the hydrocortisone given in normal saline perioperatively and as a single agent postoperatively is effective in preventing postoperative adhesions formation after microsurgical operation.
Descriptors     POSTOPERATIVE COMPLICATIONS
ADHESIONS
HYDROCORTISONE
MICROSURGERY
ANIMALS, LABORATORY
RATS
UTERUS