Author/Editor		Tepeš, B; Kavčič, B
Title		Prospectivna študija trotirne antimikrobne terapije pacientov s Helicobacter pylori pozitivnim kroničnim duodenalnim ulkusom
Translated title		Prospective study of triple antibacterial therapy in patients with Helicobacter pylori positive chronic duodenal ulcer
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. 6-7
Publication year		1994
Volume		str. 381-5
Language		slo
Abstract		Background. Helicobacter pylori (H.p.) is the main etiological cause of chronic gastritis. It may also cause postprandial, rise in serum gastrin what is followed with higher acid output. Acid production causes gastric metaplasia in duodenal bulb which is a defence reaction to hyperacidity. The gastric metaplasia in duodenal bulb can be colonized with H. p. This causes active chronic gastritis and is a place of the lowest resistance in duodenum. The result is duodenal ulcer which can not be definitely cured without eradication of H. p. Methods. From October 1990 till April 1991 I treated with antimicrobial therapy (colloidal bismuth subsitrate (CBS) 120 mg QID, amoxycillin 375 mg TID for 4 weeks and metronidazole 250 mg QID for 2 weeks) 12 patients with chronic duodenal ulcer disease (meanage 47.3 years and average duration of duodenal ulcer disease 9 years). All of them had at least one ulcer relapse a year. The second group was treated from April 1991 with 2-weeks therapy regimen (CBS 120 mg QID, amoxycillin 500 mg QID metronidazole 500 mg QID). 35 patients with mean age 43.2 years had average duration of duodenal ulcer disease 11.2 years with at least one relapse a year. All the patients in both groups had the diagnose made by histologic confirmation of H. p. with Warthin-Starry silver stains and rapid urease test. The success of eradication was proved with the control endoscopy and negative histology according to Sydney recommendations. 22 patients have come to a control endoscopy with biopsies after at least one year of follow-up. Results. The eradication rate in the first group is 11-12 patients (91.6 per cent), in the second group 34-35 patients (97 per cent). 49 per cent of all patients had minor side-effects during the treatment. The reason for high eradication rate especially for the second group is in very high personal motivation for success of the treatment and higher dose of metronidazole than in similar studies. The result of H. p.(trunc.)
Descriptors		DUODENAL ULCER HELICOBACTER PYLORI BISMUTH METRONIDAZOLE AMOXICILLIN GASTRITIS DRUG THERAPY, COMBINATION