Author/Editor		Cvenkel, Barbara; Šket-Kontestabile, Alenka
Title		Meritev debeline plasti retinalnih živčnih vlaken s 3D fourierjevo optično koherenčno tomografijo (OCT)
Translated title		Retinal nerve fiber layer thickness measurement using 3D fourier - domain optical coherence tomography (OCT)
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 79, št. Suppl
Publication year		2010
Volume		str. I-96-103
Language		slo
Abstract		Background: Recently, high-speed, high-resolution Fourier-domain 3D-optical coherence tomography (OCT) has been introduced to improve OCT quality. It can provide 6x6 mm highdensity scans to calculate retinal nerve fibre layer (RNFL) thickness measurements. The aim of the study was to measure peripapillary RNFL thickness with Topcon 3D-OCT 1000 in normal subjects and glaucoma patients. Methods: Nineteen control subjects (19 eyes) and 51 glaucoma patients (51 eyes) with different stage of glaucoma were included into the study. High-density 6x6 mm 3D-scans of the optic disc were taken. RNFL thickness was measured for 6 areas of the 3.4 mm circle and for 9 areas corresponding to the ETDRS plot centered on the optic disc. Mean RNFL thickness values were calculated for ring 1 (consisting of areas 2-5) and the outer ring (ring 2, consisting of areas 6-9) of the ETDRS plot. Results: Mean RNFL in the control group was 90microm (SD 11µm; range 63-111microm) and 61 microm (SD 21microm; range 18-100microm) in the glaucoma group for the 3.4 mm circle scan and was significantly different between the 2 groups for all areas of the RNFL circle and ETDRS plot. The differences between different stages of glaucoma were most pronounced in ring1 and area 4 of the ETDRS plot. The best parameters for differentiating normal from glaucoma eyes were ring 1 values (area under receiver operator characteristic curves (AUC) = 0.944) and area 2 values (AUC= 0.906). At 80 % and 91 % specificities ring 1 values were also the best parameter for detection of preperimetric and early glaucoma with 84 % and 74 % sensitivities, respectively. Conclusions: 3D-OCT RNFL thickness measurement showed good sensitivity and specificity in patients with early glaucoma and confirmed glaucomatous damage in patients with glaucomatous optic disc changes and normal visual field.
Descriptors		RETINA TOMOGRAPHY FOURIER ANALYSIS SENSITIVITY AND SPECIFICITY