Author/Editor		Zupan, Marija; Gril, Alenka
Title		Glavkom in možnosti nevroprotektivnega zdravljenja
Translated title		Glaucoma and options for neuroprotective treatment
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 79, št. Suppl
Publication year		2010
Volume		str. I-135-58
Language		slo
Abstract		Background: Glaucoma is a chronic progresssive optic neuropathy that often progresses despite lowering of intraocular pressure (IOP) to target levels. A need exists for therapies that prevent or limit the damage due to glaucoma, independent of therapies that simply lower IOP. The aim of neuroprotection in glaucoma is to slow down the progression by blocking the mechanisms that lead to apoptosis. Conclusions: The neuroprotective effect was demonstrated with brimonidine and betaxolol in clinical trial till now. Ginkgo biloba showed improvement of visual field damage in clinical studies on a small number of patients with NTG. Intravitreal application of Pralnacasan showed reduced ganglion cell apoptosis in an animal model with induced glaucoma. Vaccination with Glatiramer acetate has entered phase 2 trials for use in glaucoma patients.
Descriptors		GLAUCOMA INTRAOCULAR PRESSURE OCULAR HYPERTENSION GLUTAMATES NITRIC OXIDE FREE RADICALS