Author/Editor		Kovač, J; Arnol, M; Vidan-Jeras, B; Bren, A; Kandus, A
Title		Pretransplant soluble CD30 serum concentration does not affect kidney graft outcomes 3 years after transplantation
Type		članek
Source		Transplant Proc
Vol. and No.		Letnik 42, št. 10
Publication year		2010
Volume		str. 4043-6
Language		eng
Abstract		Introducrion: An elevated serum concentration of soluble the form of CD30 (sCD30), an activation marker of mainly T(H)2-type cytokines producing T lymphocytes, has been reported as a predictive factor for acute cellular rejection episodes and poor graft outcomes in kidney transplantation. This historic cohort study investigated the association of a pretransplant sCD30 serum concentrations with kidney graft function and graft survival 3 years posttransplantation in adult recipients of deceased donor kidney grafts, treated with monoclonal anti-CD25 antibodies as an induction treatment combined with a cyclosporine (CsA)-based maintenance triple therapy. Materials and methods: The pretransplant sera of 296 recipients were tested for sCD30 content using a microsphere flow-cytometry assay. The estimated glomerular filtration rate (eGFR) was determined by the 4-variable Modification of Diet in Renal Disease equation. The incidences of graft loss were calculated with the use of Kaplan-Meier survival analysis and compared using the log-rank test. Results: According to the distribution of the pretransplant sCD30 levels concentration >/=2700 pg/mL was defined as high (n = 146) and concentration <2700 pg/mL as low (n = 150). Three years posttransplantation, the eGFR was not significantly different in the recipients in high and low sCD30 groups (65 +/- 24 vs 67 +/- 21 mL/min/1.73 m(2); P = .43); there was no association between the eGFR 3 years after transplantation and the pretransplant sCD30 levels (r(2) = 0.002; P = .49). Graft survival 3 years after transplantation was also not different in the recipients in high and low sCD30 groups (P = .52). Conclusion: In our adult deceased-donor kidney graft recipients, the pretransplant sCD30 serum concentration was not a predictive factor of immunologic risk associated with the kidney graft function 3 years posttransplantation; neither did it affect graft survival 3 years after transplantation. (Abs. trunc. at 2000 ch.)
Descriptors		KIDNEY TRANSPLANTATION ANTIGENS, CD30 GRAFT REJECTION GRAFT SURVIVAL GLOMERULAR FILTRATION RATE FLOW CYTOMETRY COHORT STUDIES