Author/Editor		Dolenšek, J; Podnar, T; Runovc, F; Kordaš, M
Title		Analog simulation of aortic and of mitral regurgitation
Type		članek
Source		Comput Biol Med
Vol. and No.		Letnik 39, št. 5
Publication year		2009
Volume		str. 474-81
Language		eng
Abstract		By using an equivalent electronic circuit either mitral or aortic regurgitation was simulated. Simulation allowed not only a measurement of various pressures within the cardiovascular system and cardiac output, but also mitral and aortic flow. In normal conditions mitral and aortic flows were monophasic, anterograde. In valve regurgitation mitral and aortic flows were, as expected, biphasic. In mitral regurgitation, during systole and diastole the valve flow was retrograde and anterograde, respectively. In aortic regurgitation, during systole and diastole the valve flow was anterograde and retrograde, respectively. The magnitude of the regurgitant valve flow was measured by time-integration and compared to the net flow, i.e. cardiac output. Valve flow was determined not only by the magnitude of valve dysfunction, but also by the resistive/capacitive characteristics of the falsely attached regurgitant circuit. If the regurgitant valve flow was large enough, it in turn affected the function of the left ventricle. The present investigation suggests that many features observed in patients with mitral or aortic regurgitation can be qualitatively satisfactorily simulated. In some respects even quantitative simulation is possible. However, for simulation of chronic mitral or aortic regurgitation, in the analog electronic circuit additional adjustments-in capacitance of the left ventricle and pulmonary system--would be required.
Descriptors		COMPUTER SIMULATION MODELS, CARDIOVASCULAR ALGORITHMS AORTIC VALVE AORTIC VALVE INSUFFICIENCY BLOOD PRESSURE CORONARY CIRCULATION DIASTOLE HEART MITRAL VALVE MITRAL VALVE INSUFFICIENCY SOFTWARE SYSTOLE