Author/Editor		Kadrnka-Lovrenčić, M; Stipančić, G; Beara-Lasić, L; Vignjević, D; Lovrenčić, M
Title		Treatment of children with central precocious puberty by a slow-release gonadotropin-releasing hormone agonist
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. Suppl 1
Publication year		1994
Volume		str. I-41-I-44
Language		eng
Abstract		Background. The aim of therapy of precocious puberty is to stop the progression of puberty in order to prevent the short final stature and the associated psychosocial problems. In the present study the value of slow-release analogue of gonadotropin-releasing hormone (LHRH), Decapeptyl CR, which can induce a selective and reversible suppression of the pituitary gonadal axis and thus progression of puberty, was evaluated. Methods and results. Seven girls aged from 4.75 to 9.21 years with central precocious puberty were treated for 6 to 24 months with a slow-release gonadotropin-releasing agonist Decapeptyl CR every 4 weeks intramuscularly in a dose of 60-80 micro g/kg. During treatment, the bone maturation slowed, height velocity decreased and predicted adult height improved in all cases except one. In another patient with both growth hormone deficiency and central precocious puberty treated with LHRH agonist and growth hormone, bone maturation was normalised and predicted adult height significantly increased. A rapid decrease in breast enlargement and a halt in pubic hair development were observed. Side effects of Decapeptyl CR were minimal. Conclusions. Treatment with Decapeptyl CR was very effective in the long-term suppression of gonadal activity in children with central precocious puberty. Secondary sex characteristics showed no progression during treatment, and predicted adult height increased in most of patients.
Descriptors		PUBERTY, PRECOCIOUS GONADORELIN BODY HEIGHT BODY WEIGHT CHILD