| Author/Editor | Kržišnik, C; Jereb, B; Bratanič, N; Petrič-Grabnar, G; Battelino, T; Žerjav-Tanšek, M; Anžič, J | |
| Title | Endocrinopathies in patients after treatment for Hodgkin's disease and sarcomas in childhood | |
| Type | članek | |
| Source | Zdrav Vestn | |
| Vol. and No. | Letnik 63, št. Suppl 1 | |
| Publication year | 1994 | |
| Volume | str. I-45-I-49 | |
| Language | eng | |
| Abstract | Background. In patients treated for Hodgkin's disease (HD) and soft tissue and bone sarcomas (SA) in childhood by surgery, chemotherapy and radiotherapy late sequelae including endocrine dysfunction are common. Patients and methods. Standard endocrionological tests were used to determine endocrine function in 23 patients, 14 (4 females, 10 males) treated for HD and 9 (2 females, 7 males) for SA. In this group, 8 patients were suffering from sarcoma of the soft tissue and one from osteogenic sarcoma. The mean age at diagnosis for the patients with HD was 10.4years (range 5.0 to 14.0), while for the patients with SA it was 9.5 years (range 5.0 to 13.2). The mean age at the time of the follow-up examination for the patients with HD was 22.2 years (range 17.3 to 30) and 18.8 years (range 16 to 22) for the patients with SA. The evaluation was performed at least 5 years after the treatment, the mean interval being 11. 7 years (range 5-21) for the patients with HD, and 9.3 years (range 6-12) for the patients with SA. Results. Endocrine dysfunction was found in over 80 per cent of all treated, and it was clinically evident only in 26 per cent. We detected a high prevalence of hypothalamo pituitary gonadal dysfunction due to gonadal lesion comprising 11 (78.6 per cent) patients with HD and 7 (77.8 per cent) patients with SA. Thyroid dysfunction was found in 7 (30.4 per cent) patients examined, primary latent hypothyrnidism in 3 patients with HD and in 2 with SA, secondary hypothyroidism in one patient with HD and in one with SA. There were 2 cases of adrenal dysfunction, one in a patient with HD and one in patient with SA. Pituitary dwarfism with diminished levels of growth hormone and IGF I was found in one patient treated for SA. Conclusion.(trunc.) | |
| Descriptors | HODGKIN'S DISEASE SARCOMA ENDOCRINE DISEASES CHILD THYROID FUNCTION TESTS SOMATOTROPIN HYPOTHALAMO-HYPOPHYSEAL SYSTEM PITUITARY-ADRENAL SYSTEM |