Author/Editor		Božič-Mijovski, Mojca
Title		Hyperhomocysteinemia and thrombophilia
Type		članek
Source		Clin Chem Lab Med
Vol. and No.		Letnik 48, št. Suppl 1
Publication year		2010
Volume		str. 89-95
Language		eng
Abstract		It is now widely accepted that hyperhomocysteinemia (HHC) is a risk factor for thrombophilia. HHC is the result of either impaired enzyme function or a deficiency of vitamin B (folate, B6, Bd, or both, and can be treated with vitamin supplements. Measuring plasma total homocysteine (dIcy) is included in the routine thrombophilia panel in many laboratories, despite having a limited value to the clinician. Many methods are available for tHcy measurements. High-pressure liquid chromatography (HPLC) with fluorescence detection is a widely used method, but is being replaced by more convenient irrununo- or enzyrne assays. In this paper a general overview on homocysteine is gi ven, with an emphasis on laboratory methods.
Descriptors		HOMOCYSTEINE THROMBOSIS CHROMATOGRAPHY, HIGH PRESSURE LIQUID ENZYME-LINKED IMMUNOSORBENT ASSAY COLORIMETRY METHIONINE VITAMIN B DEFICIENCY