| Author/Editor | Bisdas, Sotirios; Konstantinou, Giorgos; Šurlan-Popović, Katarina; Khoshneviszadeh, Arjang; Baghi, Mehran; Vogl, Thomas J; Koh, Tong San; Mack, Martin G | |
| Title | Dynamic contrast-enhanced CT of head and neck tumors: comparison of first-pass and permeability perfusion measurements using two different commercially available tracer kinetics models | |
| Type | članek | |
| Source | Acad Radiol | |
| Vol. and No. | Letnik 15, št. 12 | |
| Publication year | 2008 | |
| Volume | str. 1580-9 | |
| Language | eng | |
| Abstract | Rationale and objectives: To evaluate the interchangeability of perfusion parameters between two software packages for the postprocessing of dynamic contrast-enhanced (DCE) computed tomographic images of head and neck tumors. Materials and methods: DCE computed tomographic images of 75 patients with head and neck tumors were postprocessed using a software package based on the maximum-slope approach and Patlak analysis, as well as a software package with deconvolution-based analysis incorporating an adiabatic approximation of tissue homogeneity (ATH) model. The evaluated perfusion parameters included blood flow (F), blood volume (v), and permeability-surface area product (PS). Region-of-interest (ROI) analysis of the tumors and the metastatic lymph nodes was performed. The perfusion parameters were compared using the Wilcoxon matched-pairs test and Bland-Altman plots. Results: One hundred fifty-two ROIs of tumors and nodes were outlined and analyzed. Moderate to good correlations were demonstrated between the various perfusion values (r = 0.56-0.72, P < .0001). The Wilcoxon test revealed a significant difference between the two methods (P < .001), with the F, v, and PS values obtained using the maximum-slope approach and Patlak analysis higher than those obtained using deconvolution-based analysis with the assumptions of the ATH model. The Bland-Altman plots for F and v values revealed a proportionality trend with outliers, which were strongly associated with the magnitudes of the parameters. Analysis of the PS values did not show any systematic bias. Conclusion: There were significant differences in the perfusion parameters obtained using the two software packages, and thus, these parameters are not directly interchangeable. | |
| Descriptors | MODELS, BIOLOGICAL ADULT ALGORITHMS COMPUTER SIMULATION CONTRAST MEDIA HEAD AND NECK NEOPLASMS KINETICS METABOLIC CLEARANCE RATE PERFUSION PERMEABILITY RADIOGRAPHIC IMAGE ENHANCEMENT RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED REPRODUCIBILITY OF RESULTS SENSITIVITY AND SPECIFICITY TOMOGRAPHY, X-RAY COMPUTED |