Author/Editor		Bisdas, Sotirios; Šurlan-Popović, Katarina; Didanovič, Vojko; Vogl, Thomas J
Title		Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle quantitative measurements, inter- and intra-observer agreement
Type		članek
Source		Eur Radiol
Vol. and No.		Letnik 18, št. 10
Publication year		2008
Volume		str. 2241-50
Language		eng
Abstract		Our purpose was to determine the repeatability of squamous cell cancer in head and neck (SCCHN) and muscle tissue vascularity measurements as well as the inter- and intra-observer agreement using dynamic contrast-enhanced (DCE) multi-detector CT (MDCT). Twelve patients with histologically proven SCCHN were twice examined within 46 h. Measurement error and repeatability were assessed for each of the four functional parameters using the Bland-Altman plots. Two independent observers recorded the vascularity values of the tumor tissue; inter- and intra-observer agreement was assessed using the Bland-Altman plot analysis and intraclass correlation coefficients. For the tumor, the mean difference (95% limits of agreement) was 0.40 ml/min/100 g tissue (-6.80, 9.60); 0.01 (-0.96, 0.97) ml/100 g tissue; 0.20 (-1.80, 2.30) s; and 0.40 (-2.00, 2.80) ml/min/100 g tissue for BF, BV, MTT, and PS, respectively. For the muscle, the mean difference (95% limits of agreement) was -0.18 (-1.70, 1.35), 0.04 (-1.17, 1.35), -0.10 (-5.80, 5.60), and -0.10 (-2.20, 2.00), respectively. Measurement changes of at least +/-8%, 30%, 36%, and 13% were found to be significant for BF, BV, MTT, and PS, respectively. There was better intra- than inter-observer agreement.
Descriptors		CARCINOMA, SQUAMOUS CELL CONTRAST MEDIA HEAD AND NECK NEOPLASMS IOPAMIDOL NECK MUSCLES OBSERVER VARIATION REPRODUCIBILITY OF RESULTS SENSITIVITY AND SPECIFICITY TOMOGRAPHY, X-RAY COMPUTED