Author/Editor		Goličnik, Marko
Title		Explicit analytic approximations for time-dependent solutions of the generalized integrated Michaelis-Menten equation
Type		članek
Source		Anal Biochem
Vol. and No.		Letnik 411, št. 2
Publication year		2011
Volume		str. 303-5
Language		eng
Abstract		Various explicit reformulations of time-dependent solutions for the classical two-step irreversible Michaelis-Menten enzyme reaction model have been described recently [M. Golicnik, Anal. Biochem. 406 (2010) 94-96]. In this study, I present further improvements in terms of a generalized integrated form of the Michaelis-Menten equation for computation of substrate or product concentrations as functions of time for more real-world, enzyme-catalyzed reactions affected by the product. The explicit equations presented here can be considered as a simpler and useful alternative to the exact solution for the generalized integrated Michaelis-Menten equation when fitted to time-course data using standard curve-fitting software.
Descriptors		ENZYME ACTIVATION TIME FACTORS SOLUTIONS KINETICS CATALYSIS COMPUTER SIMULATION