Author/Editor		Skok, Pavel
Title		Peptična razjeda in okužba s Helicobacter pylori
Translated title		Peptic ulcer and Helicobacter pylori infection
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 49, št. 4
Publication year		2010
Volume		str. 503-10
Language		slo
Abstract		Gastric and duodenal peptic ukers are arnong the most frequent diseases of mankind. Etiological causes for deep gastric and duodenal mucosallesions are heterogeneous, and among them Helicobacter pylori infection and the use of nonsteroidal-antiinf1ammatory drugs are most important. Infection with this bacterium is accepted as the main etiological factor for different diseases of the upper digestive tract, including gastric cancer. The majority of countries, along with Slovenia, have accepted national guidelines for the treatment of this infection a1ready a decade ago. The indications for its eradication are absolute and elective. Among absolute indications are gastric and duodenal uker disease, MALT lymphoma, atrophic gastritis and gastric cancer, while elective indications include functional dyspepsia, gastroesophageal reflux disease and treatment with nonsteroidal-antiinflammatory drugs. Triple antimicrobial therapies based on proton pump inhibitors and two antibiotics are accepted as the therapy of choice. The results of eradication therapies depend on the local Helicobacter pylori resistance rate to antibiotics and patient compliance. The article presents the causes of peptic uker, effects of H. pylori colonization of upper gastrointestinal tract mucosa, indications and the most commonly used drug combinations for its eradication.
Descriptors		PEPTIC ULCER HELICOBACTER INFECTIONS HELICOBACTER PYLORI