Author/Editor		Costa, A; Martignoni, E; Botticelli, AR; Barbolini, G; Broich, G; Ottaviani, F; Nappi, G
Title		Nasal mucosa in cluster headache: morphological changes and content of vasoactive substances
Type		članek
Source		In: Pogačnik T, Žvan B, editors. Current views on headache. Proceedings of the joint meeting Italy - Slovenia; 1994 Febr 11-12. Ljubljana: University medical centre,
Publication year		1994
Volume		str. 81-5
Language		eng
Abstract		Cluster Headache (CH) is a primary headache characterised by peculiar pattern of activity and symptom protile of attacks. The mechanisms underlying nasal congestion and rhinorrhea, symptoms most frequently experienced during the attacks, are still poorly understood. We evaluated the morphological aspects of nasal Mucosa obtained from either side in 5 drug-free male patients suffering from CH, namely 2 episodic CH (active phase) and 3 chronic CH, according to the criteria of the International Headache Society (IHS). Tissue content of substance P and the vasoactive peptides neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) was also measured using immunohistochemistry. The morphological study revealed a reduced glandular component, due to hypotrophy and fibrosis of serosal glands on hoth sides. We found no change in VIP and CGRP content, whereas a clear decrease in SP and NPY content in the nerve endings was observed in all CH patients. This was seen to be more pronounced on the side of the usual pain attacks. These data suggest that in CH the occurrence of rhinorrhea may not reflect increased activity of serosal glands, but rather oedemal/vasomotor phenomena located in the turbinate. The functional significance of changes in mediators within nasal mucosa is also discussed.
Descriptors		CLUSTER HEADACHE NASAL MUCOSA