Author/Editor		Vogrin, Matjaž; Rupreht, Mitja; Dinevski, Dejan; Hašpl, Miroslav; Kuhta, Matevž; Jevšek, Marko; Knežević, Miomir; Rožman, Primož
Title		Effects of a platelet gel on early graft revascularization after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind, clinical trial
Type		članek
Source		Eur Surg Res
Vol. and No.		Letnik 45, št. 2
Publication year		2010
Volume		str. 77-85
Language		eng
Abstract		Background: Slow graft healing in bone tunnels and a slow graft ligamentization process after anterior cruciate ligament (ACL) reconstruction are some of the reasons for prolonged rehabilitation. Aims: The purpose of this study was to determine if the use of platelet gel (PG) accelerates early graft revascularization after ACL reconstruction. Methods: PG was produced from autologous platelet-rich plasma and applied locally. We quantitatively evaluated the revascularization process in the osteoligamentous interface zone in the bone tunnels and in the intra-articular part of the graft by means of contrast-enhanced magnetic resonance imaging (MRI). Results: After 4-6 weeks, the PG-treated group demonstrated a significantly higher level of vascularization in the osteoligamentous interface (0.33 +/- 0.09) than the control group (0.16 +/- 0.09, p < 0.001). In the intra-articular part of the graft, we found no evidence of revascularization in either group. Conclusion: Locally applied PG enhanced early revascularization of the graft in the osteoligamentous interface zone after ACL reconstruction.
Descriptors		ANTERIOR CRUCIATE LIGAMENT PLATELET-DERIVED GROWTH FACTOR TRANSPLANTATION, AUTOLOGOUS