Author/Editor | Loew, O; Gabler, U; Mueller, A; Gabler, P; Schubert, H; Loew, H-C; Machnik, G | |
Title | Morphometry of connective tissue in rat livers | |
Type | članek | |
Source | Acta Stereol | |
Vol. and No. | Letnik 13, št. 1 | |
Publication year | 1994 | |
Volume | str. 101-6 | |
Language | eng | |
Abstract | Thioacetamide (TAA) induced fibrosis in the rat liver was used as a model for testing preparations for a prevention of cirrhosis. The homogeneity of collagen distribution between the lobes allows the morphometry of a single lobe as a measure for the total organ, but it is always better to estimate about 5 stage sections with equal distances, and these sections should be measured totally. A test period of 3 months results in a markable fibrosis, sufficient for testing antifibrotic preparations. Zinc ions in drinking water decrease the collagen percentages in comparison to untreated animals and reduce the TAA-induced fibrosis during simultaneously application over a 3 month period, since an addition only in the 3rd month diminishes this effect. No differences are seen after an interruption of the TAA-poisoning after 3 months and a feeding with zinc sulphate only in the 4th month, compared to clear drinking water. | |
Descriptors | LIVER THIOACETAMIDE LIVER CIRRHOSIS ANIMALS, LABORATORY RATS ZINC COMPOUNDS HISTOLOGICAL TECHNIQUES CONNECTIVE TISSUE |