Author/Editor		Meden-Vrtovec, H
Title		Obravnava žensk v klimakteriju
Translated title		Treatment of climacteric women
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. 10
Publication year		1994
Volume		str. 587-94
Language		slo
Abstract		Background. In the introduction a short historical review of hormonal replacement therapy (HRT) is presented. Follow the definitions of menopause, peri- and postmenopausal periods and of the climacteric period. According to literature the average age at menopause is about 50 years in developed countries while in Slovenia it is 47.7 years which corresponds to the age at menopause in developing and underdeveloped countries. Clinical manifestations of pre- and postmenopausal periods are considered as emphasizing the interplay between estrogen deficiency and the occurence of cardiovascular diseases (CVD) as well as osteoporosis. Methods. Preventive and therapeutic effects of HRT on vasomotor symptoms, CVD and osteoporosis are discussed, taking relative risks for endometrial and breast cancer into consideration. Conclusions. All types of available HRT are presented, including estrogens, gestagens, estrogen-gestagen combined preparations and those for local application. Some alternatives to estrogens for menopausal symptoms are included assuming that perimenopausal woman should be managed by a critical and experienced physician.
Descriptors		MENOPAUSE ESTROGEN REPLACEMENT THERAPY OSTEOPOROSIS, POSTMENOPAUSAL MIDDLE AGE PREMENOPAUSE POSTMENOPAUSE CARDIOVASCULAR DISEASES