Author/Editor		Perko, Denis; Pretnar-Oblak, Janja; Šabovič, Mišo; Žvan, Bojana; Zaletel, Marjan
Title		Endothelium-dependent vasodilatation in migraine patients
Type		članek
Source		Cephalalgia
Vol. and No.		Letnik 31, št. 6
Publication year		2011
Volume		str. 654-60
Language		eng
Abstract		Background: Endothelial dysfunction could be involved in the pathophysiology of migraine. The results obtained from a few studies on endothelial dysfunction in migraine are controversial. We investigated brachial flow-mediated dilatation (FMD), which reflects systemic endothelial dysfunction, in migraine patients without comorbidities. By employing strict inclusion criteria we avoided the possible changes to FMD from confounding factors. Methods. Forty migraine patients without comorbidities (20 with and 20 without aura) and 20 healthy subjects were included. FMD of brachial arteries and carotid intima-media thickness were measured by using standard procedures. Results. We did not find any difference in FMD between migraine patients and healthy subjects (p=.96). Also, no differences were found among healthy subjects, migraine patients with aura and without aura (p=.99). Conclusion. Our study showed that systemic endothelial function is not impaired in migraine patients without comorbidities, neither in those with or without aura. Considering these findings, the investigation of cerebral endothelial function would be useful in a further investigation of the role of endothelial (dys)function in migraine pathophysiology.
Descriptors		MIGRAINE ENDOTHELIUM, VASCULAR VASODILATION BRACHIAL ARTERY CAROTID ARTERIES ADULT TUNICA INTIMA TUNICA MEDIA BLOOD FLOW VELOCITY ULTRASONOGRAPHY, DOPPLER, DUPLEX LINEAR MODELS