Author/Editor		Krstanoska, Frosina; Umek-Brcman, Irena; Fikfak, Nataša; Čeh, Marija; Preložnik-Zupan, Irena
Title		Resni neželeni učinki zdravljenja kronične levkemije z zaviralci tirozinske kinaze - prikaz primerov in pregled literature
Translated title		Severe adverse effects associated with tyrosine kinase inhibitors therapy in chronic myeloid leukaemia - case reports and literature review
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 80, št. 5
Publication year		2011
Volume		str. 413-21
Language		slo
Abstract		Background: Chronic myeloid leukaemia is a clonal myeloproliferative disorder of myeloid progenitor cells. The availability of moleculartargeted therapy with tyrosine kinase inhibitors has changed the course and treatment for patients with chronic myeloid leukemia. The long-term follow-up of adverse events amongst the kinase inhibitors played role in forming decision- making algorithms for the use of this highly effective group of therapeutics. Patients and methods: In this paper, four CML patients are presented, treated with different tyrosine kinase inhibitors. Haematologic toxicity of kinase inhibitors is the most frequent adverse effect; however, non-haematological adverse effects should also not be neglected. Conclusions: Tyrosine kinase inhibitors have changed the therapy of CML, the treatment of these patients is a long-term process. Therefore, to know adverse effects is the matter of great importance in order to promptly recognise them and treat them properly.
Descriptors		LEUKEMIA, MYELOID, CHRONIC PROTEIN-TYROSINE KINASE NEUTROPENIA THROMBOCYTOPENIA ANEMIA MIDDLE AGE EDEMA PLEURAL EFFUSION PERICARDIAL EFFUSION