Author/Editor		Dressler, F
Title		Serologic testing in the diagnosis of Lyme borreliosis
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 3, št. 1-2
Publication year		1994
Volume		str. 83-8
Language		eng
Abstract		The diagnosis of Lyme borreliosis is primarily based on clinical data. The current status of serologic testing for specific antibodies to Borrelia burgdorferi is reviewed. Enzyme-linked immunosorbent assay or immunofluorescence assay are the most commonly used screening tests. Western blotting can be used as a confirmatory test. Patients with early Lyme borreliosis are frequently seronegative at disease onset. Rising antibody titers in follow-up specimens can support the clinical diagnosis. In patients with neuroborreliosis, demonstration of intrathecal antibody production is a specific finding. Almost all patients with late Lyme borreliosis are seropositive, and seronegativity makes late Lyme borreliosis an unlikely diagnosis. Serologic testing for Lyme borreliosis is not standardized, and there is considerable interlaboratory variation in results. Still, with discriminate use, serologic testing can be very helpful in establishing the correct diagnosis.
Descriptors		LYME DISEASE SERODIAGNOSIS BORRELIA BURGDORFERI ANTIBODIES, BACTERIAL ENZYME-LINKED IMMUNOSORBENT ASSAY FLUORESCENT ANTIBODY TECHNIQUE BLOTTING, WESTERN