Author/Editor		Gorišek, Nina; Lorenčič Robnik, Slavica
Title		Urosepsa
Translated title		Urosepsis
Type		članek
Source		In: Reberšek Gorišek J, Kotnik-Kevorkijan B, editors. Okužbe urogenitalnega trakta: zbornik vabljenih predavanj in praktikum. Maribor: Univerzitetni klinični center,
Publication year		2011
Volume		str. 95-105
Language		slo
Abstract		Urosepsis is the most severe form of urinary tract infection and is associated with considerable high mortality rate. Most common pathogens are Gram-negative bacteria, members of the Enterobacteriaceae family (Escherichia coli, Klebsiella spp., Proteus spp.). Signs and symptoms of urosepsis are those of systemic inflammatory response syndrome such as fever, tachycardia, tachypnea and signs of hyperdinamic circulation together with simptoms of urinary tract infection. Early diagnosis and treatment of urosepsis are of utmost importance for the survival of patients. In urosepsis sonographic examination of urogenital tract should be performed as soon as possible to rule out the obstruction of urinary tract or other pathology. Appropriate empiric antimicrobial therapy should be selected considering risk factors for resistant microbs and dosage must be individually adjusted. We present clinical characteristcs of patients, treated for urosepsis caused by Escherichia coli, Klebsiella spp and Pseudomonas aeruginosa at the University Clinical Center Maribor in the year 2010.
Summary		Urosepsa je najtežja oblika okužbe sečil, ki j povezana z znatno umrljivostjo bolnikov. Urosepso povzročajo predvsem po Gramu negativne bakterije, zlasti iz družine Enterobacteriaceae (Escherichia coli, Klebsiella spp., Proteus spp.). Klinična slika sepse je odraz sistemskega vnetnega odziva in se lahko kaže s povišano telesno temperaturo, tahikardijo, tahipnejo, znaki hiperdinamične cirkulacije ter s kliničnimi znaki okužbe sečil. Zgodnja diagnoza in hitro zdravljenje sepse sta ključna dejavnika za uspeh terapije. Pri vseh bolnikih s klinično sliko urosepse je potrebno čim prej ugotoviti morebitno obstrukcijo sečil in jo razrešiti. Pri izkustveni izbiri antibiotika upoštevamo dejavnike tveganja za kolonizacijo z večkratno odpornimi bakterijami ter odmerek prilagodimo bolniku. V prispevku smo prikazali značilnosti bolnikov, ki so se leta 2010 zdravili v UKC Maribor zaradi urosepse, povzročene z bakterijo Escherichia coli, Klebsiella spp. ter Pseudomonas aeruginosa.
Descriptors		UROGENITAL SYSTEM SEPSIS