Author/Editor		Erman, Andreja
Title		Hitosan in možna uporaba v medicini
Translated title		Chitosan and its possible use in medicine
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 80, št. 6
Publication year		2011
Volume		str. 489-98
Language		slo
Abstract		Background: Searching for new drug formulations, which enable drug targeting to specific tissues and cells, is in full swing. Various investigations of polymers including chitosan indicate a wide applicability in the pharmaceutical field and consequently also in medicine due to its established physicochemical properties. Chitosan is a natural polymer obtained by deacetylation of chitin. Cationic nature and conformation permit chitosan to react with anionic drugs and to be a promising bioadhesive material. All this gives chitosan a potential to be a controlled delivery system for drug targeting . Conclusions: In in vitro investigations, chitosan has proved to be a succesful, safe and non-toxic drug delivery system. These results are confirmed also by recent in vivo investigations. This implies that chitosan has wide possibilities in the treatment of some urgent medical problems, such as atherosclerosis, allergies and gastric ulcers. Its succesful and safe applicability render chitosan potentially useful in the treatment of bacterial infections, in tissue engineering, immunoprophylaxis and in gene therapy.
Descriptors		DOSAGE FORMS POLYMERS CHITIN DRUG DELIVERY SYSTEMS ADHESIVES