Author/Editor		Bogataj, M; Mrhar, A; Korošec, L
Title		In vitro evaluation of bioadhesive properties of hydroxypropylcellulose and carboxymethylcellulose films and microspheres
Type		članek
Source		In: Crommelin D, Couvreur P, Duchene D, editors. In vitro and ex vivo test systems to rationalize drug design and delivery. Europen symposium; 1993 13-14 Dec; Paris. Paris: International pharmaceutical federation,
Vol. and No.		, št. 2
Publication year		1994
Volume		str. 228-31
Language		eng
Abstract		The method for measuring bioadhesive force was applied to evaluate bioadhesive properties of hydroxypropylcellulose and sodium carboxymethylcellulose films and microspheres. The guinea pig small intestine was used as mucosal tissue. The quantities of water needed for complete hidration of polymers and microspheres were also determined. Correlation with bioadhesion force for different samples of microspheres was performed, too. In addition the influence of different quantities of water used for hidration of polymers and microspheres on the bioadhesive strength was studied.
Descriptors		INTESTINAL MUCOSA ADHESIVENESS CELLULOSE MICROSPHERES PIPEMIDIC ACID STEARATES WATER