Author/Editor | Bavec, Aljoša | |
Title | Structure, function and regulation of group IV phospholipase A2 family | |
Type | članek | |
Source | Acta Chim Slov | |
Vol. and No. | Letnik 58, št. 2 | |
Publication year | 2011 | |
Volume | str. 195-202 | |
Language | eng | |
Abstract | The Group IV phospholipase A2 family is consisted of six intracellular enzymes. They catalyze hydrolysis of the sn-2 ester bond of glycerophospholipids, releasing fatty acid metabolites and lysophospholipids. Agonist-induced release of arachidonic acid for the production of eicosanoids by PLA2IValpha enzyme is important in regulating normal and pathological processes in a variety of target tissues. Here, we compare PLA2IValpha, and its paralogs beta, gamma, delta, epsilon and zeta in term of of their structure, function and regulation. | |
Summary | Skupina IV fosfolipaz A2 trenutno obsega šest encimov. Encimi katalizirajo hidrolizo sn-2 estrske vezi glicerofosfolpidov, pri čemer nastane maščobna kislina in lizofosfolipid. Največkrat je produkt hidrolize arahidonska kislina, ki se pretvarja v aktivne eikozanoide, ki imajo pomembno vlogo pri regulaciji celičnih procesov v različnih tarčnih tkivih. V tem prispevku si bomo pogledali strukturo, funkcijo in regulacijo encima PLA2IValpha in jo primerjali z ostalimi predstavniki skupine IV fosfolipaz A2, in sicer z beta, gama, delta, epsilon in zeta. | |
Descriptors | PHOSPHOLIPASES A CYTOSOL PHOSPHOLIPIDS LYSOPHOSPHOLIPIDS ARACHIDONIC ACID EICOSANOIDS |