Author/Editor		Janša, Jelka; Georgiev, Dejan; Ocepek, Lidija; Pirtošek, Zvezdan; Vidmar, Gaj
Title		A double-blind placebo-controlled cross-over study on the effects of botulinum toxin type a on upper limb disorders
Translated title		Dvojna slepa kontrolirana navzkrižna študija učinkov botulina A na bolezni zgornjih udov
Type		članek
Source		Inform Med Slov Print ed
Vol. and No.		Letnik 16, št. 1
Publication year		2011
Volume		str. 22-7
Language		slo
Abstract		Botulinum treatment has been proven to be a promising treatment for many dystonic and spastic disorders. Apart from correction of posture and pain relief, functional testing is an important part of pre - and post-treatment assessment. We report results and dilemmas of using two assessment scales in a double-blind, placebocontrolled cross-over study on 10 patients with upper limb motor disorders. While the improvement on the Arm Function Test (AFT) after the Botulinum session was not statistically significantly higher than after placebo, the difference in favour of the treatment was much more evident on the 0-5 self-assessment scale. We believe that AFT is not sufficiently sensitive or at least not superior to simpler global scales, and that measurement of focal disability does not entirely clarify functional changes after treatment with Botulinum Toxin.
Descriptors		MOVEMENT DISORDERS ARM BOTULINUM TOXIN TYPE A TREATMENT OUTCOME CROSS-OVER STUDIES DOUBLE-BLIND METHOD