Author/Editor		Kores Testen, Polona; Kovač, Vilma; Vlaisavljević, Veljko
Title		Intrauterina inseminacija - analiza in primerjava ciklov, spodbujenih s klomifen citratom ali z gonadotropini
Translated title		Intrauterine insemination - analysis and comparison of cycles stimulated with clomiphene citrate or gonadotrophins
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 80, št. Suppl 1
Publication year		2011
Volume		str. I-95-102
Language		slo
Abstract		Background: The purpose of our study was to determine the success rate of IUI depending on type of stimulation. We tried to establish the influence of infertility indications and semen quality on IUI cycle outcome. Methods: We analyzed retrospectively 1753 cycles performed in 781 infertile patients. We compared the success rate depending on indication, type of stimulation and semen quality. For statistical analysis Pearson's chi-square and MannWhitney U tests were used. Results: Pregnancy rate was 6.6 % for all indications, pregnancy rate per couple was 13.6 %. Pregnancy rate for idiopathic infertility was 7.6 %, for female infertility, male infertility and combination of the two the rates were 6.5 %, 5.4 % and 5.0 % respectively. The lowest pregnancy rate 3.4 % per cycle was achieved in couples with tubal infertility. Pregnancy rate with clomiphene citrate stimulation was 6.3 % and with gonadotrophins 10 %; 87 % of pregnancies were achieved when inseminated with semen that contained at least 2 million mobile sperm. Conclusions: IUI is a noninvasive, low-cost method. It is suitable for the treatment of idiopathic infertility, male infertility and female infertility without tubal pathology. The best results are obtained in cycles stimulated with gonadotrophins and with total motile sperm count of at least two million per catheter.
Summary		Izhodišča: Z raziskavo smo želeli oceniti uspe- šnost postopka intrauterine inseminacije (IUI) in primerjati uspešnost ciklov ob spodbujanju ovulacije sklomifen citratom ali z gonadotropini. Prav tako smo želeli ovrednotiti vplivvrste neplodnosti in kakovosti semena na izid postopka IUI. Metode: Retrospektivno smo analizirali statistične podatke 1753 ciklusov IUI, ki smo jih opravili pri 781 neplodnih parih. Analizirali smo uspešnost postopka IUIglede na indikacijo za poseg, izbrani protokol spodbujanja ovulacije in kakovost semena. Dobljene podatke smo statistično obdelali s Pearsonovim testom hi-kvadrat in Mann Whitneyevim testom U. Rezultati: Delež zanositev nacikel je znašal 6,6 % za vse indikacije, delež zanositev na par pa 13,6 %.Uspešnost IUI pri parih z idiopatsko neplodnostjo je bila 7,6 %, pri parih,pri katerih smo ugotovili izključno žensko neplodnost, izključno moško neplodnost in kombinacijo obeh, pa 6,5 %, 5,4 % in 5,0 %. Najmanj uspešni so bili postopki IUI pri ženskah z okluzijo enega jajcevoda, pri katerih je delež zanositev znašal 3,4 %. Delež zanositev na cikel ob spodbujanju s klomifen citratom je znašal 6,3 % in ob spodbujanju z gonadotropini 10 %. 87 % vseh bolnic je zanosilo, če je število gibljivih semenčic v vzorcu, pripravljenem za inseminacijo, presegalo 2 milijona. Zaključki: IUI je neinvazivna in cenovno ugodna metoda, ki je primerna za zdravljenje idiopatskeneplodnosti, ženske neplodnosti brez patologije jajcevodov in moškeneplodnosti ob učinkovitosti separacije gibljivih semenčic. Posebej učinkovita je v ciklih, spodbujenih z gonadotropini, in ob prisotnosti vsaj dveh milijonov gibljivih semenčic v vzorcu semena, pripravljenem za IUI.
Descriptors		INSEMINATION CLOMIPHENE GONADOTROPINS