Author/Editor | Nadrah, Kristina | |
Title | Novosti pri terapevtskem spremljanju koncentracij vankomicina | |
Translated title | Advances in the therapeutic monitoring of vancomycin concentrations | |
Type | članek | |
Source | Zdrav Vestn | |
Vol. and No. | Letnik 80, št. 7-8 | |
Publication year | 2011 | |
Volume | str. 571-7 | |
Language | slo | |
Abstract | Vancomycin is a glycopeptide antibiotic used for treatment of infections caused by methicillinresistant Staphylococcus aureus (MRSA). During the last decade there have been reports of glycopeptide-resistant strains of Staphylococcus aureus. In some cases there are heterogenous populations of glycopeptide-susceptible and resistant strains which cannot be differentiated by standard clinical microbiology methods, but cause treatment failure and cross-resistance to other antibiotics. In order to improve clinical successand diminish the occurence of resistance, vancomycin trough concentrations of 15-20 mg/L have been recommended. With such high trough concentrations there have been warnings and doubts about the nephro-and ototoxicity of vancomycin. The review article describes new guidelines for therapeutic monitoring of vancomycin concentrations and the scientific background of the amendments. We discuss the pharmacokinetic and pharmacodynamic characteristics of vancomycin, its toxicity and the problem of resistance. | |
Descriptors | STAPHYLOCOCCAL INFECTIONS STAPHYLOCOCCUS AUREUS VANCOMYCIN DRUG RESISTANCE, MICROBIAL KIDNEY ACOUSTIC NERVE |