Author/Editor		Serša, G; Golouh, R; Miklavčič, D
Title		Anti-tumor effect of tumor necrosis factor combined with electrotherapy on mouse sarcoma
Type		članek
Source		Anticancer Drugs
Vol. and No.		Letnik 5, št. 1
Publication year		1994
Volume		str. 69-74
Language		eng
Abstract		Anti-tumor effectiveness of tumor necrosis factor (TNF)-alpha applied peritumorally was assessed in combination with local electrotherapy on subcutaneous SA-1 tumors in mice. TNF and electrotherapy each induced significant tumor growth delay. In combined treatment using TNF and electrotherapy, a synergistic anti-tumor effect was observed, regardless of whether TNF was injected before or after electrotherapy. An extra anti-tumor effect was achieved when TNF in the same total dose (2 x 10(5) U) was split into a priming dose (0.5 x 10(5) U) 1 h before electrotherapy and the other (1.5 x 10(5) U) 24 h thereafter. As the result of this therapeutic combination survival rate of the animals was 40 percent. No animal survived more than 50 days in groups subjected to TNF or electrotherapy treatment alone. Combined treatment with TNF and electrotherapy induced massive tumor destruction, confirmed by histological examination 2 days after the treatment. The results indicate that TNF and electrotherapy interact and that they can be effective in control of local tumor growth.
Descriptors		ANTINEOPLASTIC AGENTS ELECTRIC STIMULATION THERAPY SARCOMA, EXPERIMENTAL SKIN NEOPLASMS TUMOR NECROSIS FACTOR ANTINEOPLASTIC AGENTS COMBINED MODALITY THERAPY MICE MICE, INBRED A NEOPLASM TRANSPLANTATION SARCOMA, EXPERIMENTAL SKIN NEOPLASMS TIME FACTORS TUMOR NECROSIS FACTOR