Author/Editor		Pohar-Marinšek, Ž; Golouh, R
Title		Secretory breast carcinoma in a man diagnosed by fine needle aspiration biopsy. A case report
Type		članek
Source		Acta Cytol
Vol. and No.		Letnik 38, št. 3
Publication year		1994
Volume		str. 446-50
Language		eng
Abstract		Preoperative aspiration biopsy of a breast tumor in a 20-year-old male resulted in a diagnosis of secretory breast carcinoma. The material obtained from aspiration biopsy was also used for electron microscopic, immunocytochemical and flow cytometric analysis. The characteristic light microscopic features were numerous large secretory vacuoles containing proteinaceous material, which was also seen in the background of the smear. Electron microscopy revealed numerous intracellular lumina and some intercellular ones filled with secretory material as well as membrane-bound vacuoles. Immunoreactivity was positive for cytokeratin, epithelial membrane antigen, carcinoembryonic antigen, alpha-lactalbumin and vimentin. Flow cytometric analysis showed the tumor to be diploid. The affected breast and tumor were resected, and the cytologic diagnosis was confirmed histopathologically. The cytomorphologic features of secretory breast carcinoma seem to be alike in men and women and are sufficiently characteristic to permit a definitive preoperative diagnosis from fine needle aspiration biopsy smears. The differential diagnosis with other tumors is discussed briefly.
Descriptors		BREAST NEOPLASMS CARCINOMA ADULT BREAST NEOPLASMS CARCINOMA DIPLOIDY DNA, NEOPLASM FOLLOW-UP STUDIES IMMUNOHISTOCHEMISTRY LACTALBUMIN LYMPH NODE EXCISION LYMPHATIC METASTASIS MICROSCOPY, ELECTRON S PHASE VACUOLES