Author/Editor     van Battum, P; Schaper, N; Prompers, L; Apelqvist, J; Jude, E; Piaggesi, A; Bakker, K; Edmonds, M; Holstein, P; Urbančič, V
Title     Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation
Type     članek
Source     Diabet Med
Vol. and No.     Letnik 28, št. 2
Publication year     2011
Volume     str. 199-205
Language     eng
Abstract     Objectives: The incidence of minor amputation may vary significantly, and determinants of minor amputation have not been studied systematically. We evaluated minor amputation rate, the determinants of minor amputation and differences in amputation rate between European centres. Methods: In the Eurodiale study, a prospective cohort study of 1232 patients (1088 followed until end-point) with a new diabetic foot ulcer were followed on a monthly basis until healing, death, major amputation or up to a maximum of 1 year. Ulcers were treated according to international guidelines. Baseline characteristics independently associated with minor amputation were examined using multiple logistic regression modelling. Based on the results of the multivariable analysis, a disease severity score was calculated for each patient. Results: One hundred and ninety-four (18%) patients underwent a minor amputation. Predictors of minor amputation were depth of the ulcer (odds ratio 6.08, confidence interval 4.10-9.03), peripheral arterial disease (odds ratio 1.84, confidence interval 1.30-2.60), infection (odds ratio 1.56, confidence interval 1.05-2.30) and male sex (odds ratio 1.42, confidence interval 0.99-2.04). Minor amputation rate varied between 2.4 and 34% in the centres. Minor amputation rate in centres correlated strongly with disease severity score at the moment of presentation to the foot clinic (r=0.75). Conclusions: Minor amputation is performed frequently in diabetic foot centres throughout Europe and is determined by depth of the ulcer, peripheral arterial disease, infection and male sex. There are important differences in amputation rate between the European centres, which can be explained in part by severity of disease at presentation. This may suggest that early referral to foot clinics can prevent minor amputations.
Descriptors     AGED
AMPUTATION
CONFIDENCE INTERVALS
DIABETIC FOOT
DIABETIC NEUROPATHIES
EUROPE
ODDS RATIO
PROSPECTIVE STUDIES
SEVERITY OF ILLNESS INDEX