Author/Editor		Kržišnik, Julija; Dernovšek, Mojca Zvezdana
Title		Ali je uporaba kognitivnih modulatorjev smiselna pri zdravljenju bipolarne motnje razpoloženja?
Translated title		Is the use of cognitive modulators reasonable in treatment of bipolar mood disorder?
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 50, št. 3
Publication year		2011
Volume		str. 307-13
Language		slo
Abstract		A significant proportion of patients with bipolar disorder do not respond satisfactorily to conventional pharmacological treatment with lithium, anticonvulsants, antipsychotics and antidepressants. Several studies point to high risk for chronic illness and relapse despite receiving available therapy. At this moment we do not even have a common definition for treatment-resistant bipolar disorder, which makes assessing the number of patients refractory to treatment very difficult. Not only resistance to treatment, but also the evidences of cognitive decline in chronic patients speak for the need for complementary therapies. Cognitive modulators such as donepezil, galantamine, rivastigmine and memantine are drugs that are primarily used in treating various forms of dementia. This paper collects currently available data on the use of cognitive modulators as augmentation therapy of treatment-resistant bipolar disorder and in treatment of cognitive decline in this disease. Encouraging results of studies and case reports suggest that further research into the use of cognitive modulators in bipolar mood disorder is reasonable, primarily in terms of controlled randomized double-blind studies.
Descriptors		BIPOLAR DISORDER COGNITION DISORDERS MEMANTINE GALANTHAMINE DRUG RESIDUES