Author/Editor		Denišlič, M; Meh, D; Kržišnik, C
Title		Periferne nevropatije pri otrocih s sladkorno boleznijo tipa I
Translated title		Peripheral neuropathy in type I diabetic children
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 63, št. 11
Publication year		1994
Volume		str. 665-70
Language		slo
Abstract		Background. Small and large, somatic and autonomic nerve fibre functions were neurophysiologically evaluated in 33 asymptomatic type I diabetic children, aged from 6.5 to 18.6 years (mean 13.2 q 3.0 y.). The diabetes duration was 2.8 to 14.3 years (mean 7.3 q 3.3 y.). The results were compared with results of 69 aged-matched healthy children. The aim of our study was to seek for the subclinical involvement of peripheral nervous system in type I diabetic children. Methods. All children underwent clinical neurological examination. Motor conduction velocities (MCVs), distal motor latencies (DMLs) and distal compound muscle action potential amplitudes (CMAPs) of the right median, ulnar and peroneal nerves were studied. Sensory conduction velocities (SCVs) and amplitudes of the sensory nerve action polentials (SNAPs) of the right median, ulnar and sural nerves were measured. Thermal and pain sensitivities were assessed at the following sites: the right thenar, right upper arm, right dorsum of the foot and right thigh. Autonomic nerve functions evaluation encluded the measurement of the sympathetic skin response (SSR) latency and amplitude, R-R interval variation and heart rate variation (HRV). Results. In our study significant difference between both examined groups was found. Measurements of sural sensory conduction velocities and the warm-cold difference limen determination on the thigh were the most sensitive tests (abnormal in 18 per cent of children). The SSR response showed abnormalities in 15 per cent (lower limbs) and 9 per cent (upper limbs) of the diabetic children. Su bclinical neuropathy, neurophysiologically determined according to Dyck and colleagues, was found in 45 per cent of children. There was no significant correlation between different tests results. Conclusions. Asymptomatic involvement of peripheral somatic and autonomic, large and small nerve fibres is frequent in diabetic children.(trunc.)
Descriptors		DIABETES MELLITUS, INSULIN-DEPENDENT DIABETIC NEUROPATHIES NEURAL CONDUCTION CHILD MEDIAN NERVE ULNAR NERVE PERONEAL NERVE SURAL NERVE