Author/Editor		Dernovšek, MZ; Sket, D
Title		Effects of kainic acid and of pretreatment with diazepam, MK-801 and scopolamine prior to kainic acid on the behaviour of rats with spontaneous recurrent seizures
Type		članek
Source		Acta Fac Med Flumin
Vol. and No.		Letnik 18, št. Suppl 1
Publication year		1993
Volume		str. 5-12
Language		eng
Abstract		Rats, that develop spontaneously recurrent seizures (SRS rats), were obtained by previous induction of status-epilepticus-linked lesions in the limbic system with kainic acid (KA), applied systemically (10 mg/kg s.c.). The animals treated in this way develop spontaneous recurrent seizures in several weeks. The procedure was improved by interrupting the KA-induced status epilepticus with diazepam (5 mg/kg i.m.). In this way the mortality of rats due to seizures was reduced and the number of rats, developing SRS was thus increased by 120 per cent. The response to KA in the SRS rats was qualitatively different as compared to the rats treated by the KA for the first time. The "wet dog shakes" and the epileptic status did not develop and the frequency of recurrent seizures was significantly increased in the KA-treated SRS rats. The pretreatment with diazepam (5 mg/kg i.m.), MK-801 (1 mg/kg i.p.) or scopolamine (10 mg/kg i.p.) decreased the frequency of the KA-induced seizures. The lower dose of scopolamine (1 mg/kg i.p.) was, however, ineffective. Therefore, the KA-induced recurrent seizures in the SRS rats could be a useful model for studying possible antiepileptic drugs.
Descriptors		SEIZURES KAINIC ACID SCOPOLAMINE DIZOCILPINE MALEATE DIAZEPAM ANIMALS, LABORATORY RATS EPILEPSY