Author/Editor		Kabaso, Doron; Bobrovska, Nataliya; Gozdz, Wojciech; Gov, Nir; Kralj-Iglič, Veronika; Veranič, Peter; Iglič, Aleš
Title		On the role of membrane anisotropy and BAR proteins in the stability of tubular membrane structures
Type		članek
Source		J Biomech
Vol. and No.		Letnik 45, št. 2
Publication year		2012
Volume		str. 231-8
Language		eng
Abstract		Recent studies have demonstrated that actin filaments are not crucial for the short-term stability of tubular membrane protrusions originating from the cell surface. It has also been demonstrated that promini nanodomains and curvature inducing I-BAR proteins could account for the stability of the membrane protrusion. Here we constructed an axisymmetric model of a membrane protrusion that excludes actin filaments in order to investigate the contributions of prominin nanodomains (rafts) and I-BAR proteins to the membrane protrusion stability. It was demonstrated that prominin nanodomains and I-BAR proteins can stabilize the membrane protrusion only over a specific range of spontaneous curvature. On the other hand, high spontaneous curvature and/or high density of I-BAR proteins could lead to system instability and to non-uniform contraction in the radial direction of the membrane protrusion. In agreement with previous studies, it was also shown that the isotropic bending energy of lipids is not sufficient to explain the stability of the observed tubular membrane protrusion without actin filaments.
Descriptors		BIOPHYSICS MEMBRANES, ARTIFICIAL MICROCHEMISTRY ANISOTROPY MEMBRANE PROTEINS ACTINS MICROTUBULES