| Author/Editor | Skrgatic, L; Pavicic-Baldani, D; Černe, JZ; Ferk, P; Geršak, K | |
| Title | CAG repeat polymorphism in androgen receptor gene is not directly associated with polycystic ovary syndrome but influences serum testosterone levels | |
| Type | članek | |
| Source | J Steroid Biochem Mol Biol | |
| Vol. and No. | Letnik 128, št. 3-5 | |
| Publication year | 2012 | |
| Volume | str. 107-12 | |
| Language | eng | |
| Abstract | Hyperandrogenemia has been the most consistent feature of polycystic ovary syndrome (PCOS). Androgens exert their effects through androgen receptors (AR). The expansion of the codon CAG trinucleotide repeat polymorphism in exon 1 of the AR gene represents a type of genetic alteration associated with changes in the AR gene function. The purpose of this studywas to establish a possible association of the AR gene CAG repeat length polymorphism with PCOS, and its influence on clinical and biochemical androgen traits. Two hundred and fourteen Croatian women with PCOS and 209 healthy control women of reproductive age were enrolled. Phenotypic hyperandrogenism, BMI and waist-to hip ratio were recorded. Hormonal profiles, fasting insulin and glucose levels were measured on cycle day 3-5. Genotyping of the CAG repeat polymorphism in the AR gene was performed. We found no significant difference in the mean CAG repeat number between the PCOS patients and controls (22.1±3.4 vs. 21.9±3.2, P=0.286). There was a positive correlation between the CAG repeat length and total testosterone (TT) in the PCOS group (R=0.225, P=0.015). A multiple linear regression model using mean CAG repeat length, BMI, age and HOMA - IR as predictors explained 8.5 % (adjusted R2) of the variability in serum TT levels. In this model the CAG repeat polymorphism was found to be a significant predictor of serum TT levels in PCOS patients (P=0.015). The logistic regression analysis revealed that the CAG repeat length is not a significant predictor of hirsutism and acne status (P=0.921 and P=0.437, respectively). The model was adjusted for serum TT, free testosterone, androstendione and DHEAS levels as independent variables, which were also not found to be significant predictors of hirsutism (P = 0.687, P = 0.194, P = 0.675 and P = 0.938, respectively) or acne status (P = 0.594, P = 0.095, P = 0.290 and P = 0.151, respectively). (Abstract truncated at 2000 characters) | |
| Descriptors | POLYCYSTIC OVARY SYNDROME HYPERANDROGENISM RECEPTORS, ANDROGEN TESTOSTERONE POLYMORPHISM (GENETICS) ADULT PHENOTYPE GENOTYPE ANDROSTENEDIONE DEHYDROEPIANDROSTERONE SULFATE |