Author/Editor     Springer, Jochen; Lainščak, Mitja; Salobir, Barbara; Lang, Irene M
Title     Treatment of pulmonary hypertension: bench to bedside
Type     članek
Source     Respir Med
Vol. and No.     Letnik 105, št. Suppl 1
Publication year     2011
Volume     str. S7-11
Language     eng
Abstract     Pulmonary arterial hypertension is an orphan disease and a model for drug developments over recent years. Expert centers have focused basic science on the pulmonary vasculature and the right ventricle, followed by a direct transfer of innovative concepts to clinical research. Successful examples for translational experimentation are the endothelin receptor antagonists, prostacyclin receptor agonists, and the activators of soluble guanylate cyclase. On the other hand, there have been failures such as vasoactive intestinal peptide, statins, and escitalopram. Several new drugs and gene therapy are under investigation, thus significant advances are anticipated.
Descriptors     HYPERTENSION, PULMONARY
VASODILATOR AGENTS
EPOPROSTENOL
ENDOTHELINS
PHOSPHODIESTERASE INHIBITORS
ESTRADIOL
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS