Author/Editor		Peterlin, BM; Price, DH
Title		Controlling the elongation phase of transcription with P-TEFb
Type		članek
Source		Mol Cell
Vol. and No.		Letnik 23, št. 3
Publication year		2006
Volume		str. 297-305
Language		eng
Abstract		The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made possible by the reversal of effects of negative elongation factors that include NELF and DSIF. In complex organisms, elongation control is critical for the regulated expression of most genes. In those organisms, the function of P-TEFb is influenced negatively by HEXIM proteins and 7SK snRNA and positively by a variety of recruiting factors. Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns.
Descriptors		GENE EXPRESSION REGULATION ANIMALS PHYLOGENY RNA POLYMERASE II TRANSCRIPTION FACTORS TRANSCRIPTION, GENETIC