Author/Editor		Bartoš, V; Pokorny, D; Zacharova, O; Haluska, P; Doboszova, J; Kullova, M; Adamicova, K; Peč, M; Peč, J
Title		Reccurent basal cell carcinoma: A clinicopathological study and evaluation of histomorphological findings in primary and recurrent lesions
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 20, št. 2
Publication year		2011
Volume		str. 67-75
Language		eng
Abstract		Background: Basal cell carcinoma (BCC) of the skin is now the most common malignancy in the human population. One of the most negative features of this disease is frequent tumor recurrence. Unfortunately, all of the traditional diagnostic criteria have failed to definitively predict which patients should be considered at high risk of recurrence. Object: The aim of this study was to evaluate the prevalence, topographical localization, and histomorphological features of recurrent BCCs. METHODS: Biopsy samples and clinical data from 30 consecutive patients (15 women and 15 men) with 31 recurrent BCCs diagnosed from January 2007 to September 2010 were analyzed retrospectively. The mean age of the individuals at the time of diagnosis of recurrence was 68.2 years (range 32 to 97 years). Histological types and other pathological findings of original and relapsing BCCs, as well as the time between them, were able to be compared in 24 cases. Re: Recurrent carcinomas represented 4.9% of all diagnosed cases during the observed period. Recurrence time varied from 4 to 105 months with a mean time of 31.2 months. The majority of recurrences occurred within 3 years after the primary treatment. The topographic localization of tumors was as follows: auricles (n = 5), cheeks (n = 4), medial canthus (n = 4), periauricular regions (n = 3), temporal areas (n = 3), paranasal regions (n = 3), nose (n = 3), forehead (n = 1), lower eyelid (n = 1), mandible (n = 1), chin (n = 1), neck (n = 1), and back (n = 1). Histologically, 50% of primary and 54.8% of recurrent BCCs demonstrated at least partial aggressive-growth features. Comparing primary and corresponding relapsing BCCs, 50% of them showed an identical type, in 16.7% the recurrent tumor had developed a more aggressive histological picture, and in 20.8% the histomorphology had became more benign. (Abstract truncated at 2000 characters)
Descriptors		SKIN NEOPLASMS CARCINOMA, BASAL CELL NEOPLASM RECURRENCE, LOCAL RETROSPECTIVE STUDIES