Author/Editor		Torlone, G; d'Alessandro, I; Rossodivita, A; Peris, K; Chimenti, S
Title		Merkel cell (neuroendocrine) carcinoma of the skin
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 3, št. 3
Publication year		1994
Volume		str. 165-9
Language		eng
Abstract		An 81-year-old woman presented with a 3 months history of an erythematous indurated plaque, with isolated and confluent nodules, located on the right leg. The lesion measured 8 x 12 cm and was asymptomatic. Histologic examination of a skin biopsy specimen showed a diffuse, dense infiltrate through the whole dermis to the subcutis, composed of medium-small cells, with round or oval nucleus and ill-defined cytoplasm. A focal trabecular pattern was also seen. Immunohistochemical positive reactions for anticytokeratins (CK), neurofilaments (NF) and neuron specific enolase (NSE) antibodies were detected. Electron microscopy revealed membrane-bound, dense-core neurosecretory granules, paranuclear whorls of intermediate filaments, and poorly formed desmosomes. Routine laboratory examinations were within normal limits. Esophagogastroscopy and computed tomographic (CT scans of the chest and abdomen showed no abnormalities. On the basis of clinicopathologic and ultrastructural findings, a diagnosis of Merkel cell carcinoma was established. The patient was treated with radiotherapy on the right leg and inguinal lymph nodes (50 Gy total dose in 25 fractions over 5 weeks). Complete regression of cutaneous lesion was achieved, and after a follow up period of 1 year no recurrence has been observed.
Descriptors		SKIN NEOPLASMS CARCINOMA, MERKEL CELL