Author/Editor		Šmid, Lojze M; Bresjanac, Mara
Title		Razvoj zaživljenjske diagnostike bolezenskih beljakovinskih odlag v možganih: prionske bolezni: komentar
Translated title		Development of in vivo diagnosis of pathologic protein deposits in the brains of prion disease patients: commentary
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 80, št. 12
Publication year		2011
Volume		str. 971-4
Language		slo
Abstract		Translational medicine is a term describing systematic efforts for adequate testing and transfer of basic research findings into dinical practice. The paper outlines a series of studies aimed at evaluating adiagnostic potential of positron emission tomography with a radioisotope probe (18F)FDDNP for early recognition of pathologic protein deposits in the brain s of prion disease patients. Slovene scientists contributed significantly to all studies in this bench-to-bedside sequence of translational neuroscience.
Summary		Translacijska medicina obsega sistematična prizadevanja za ustrezno preverbo in prenos raziskovalnih spoznanj temeljnih raziskav v uporabno medicinsko prakso. Prispevek orisuje raziskave diagnostične uporabnosti pozitronske izsevne tomografije z radioizotopsko označenim molekulskim sledilcem [18F]FDDNP za zgodnjo zaživljenjsko prepoznavo bolezenskih beljakovinskih odlag v možganih bolnikov s prionskimi boleznimi. Raziskave, v katerih imajo pomembno vlogo tudi slovenski znanstveniki, so peljale od laboratorijskih poskusov do klinične študije in predstavljajo dober primer translacijske nevroznanosti.
Descriptors		PRION DISEASES PRIONS TOMOGRAPHY, EMISSION-COMPUTED