Author/Editor		Flašker, Ajda; Rituper, Boštjan; Zorec, Robert
Title		Vpogled v uravnavano eksocitozo: vloga lipidov
Translated title		Insight into regulated exocytosis: role of lipids
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 50, št. 4
Publication year		2011
Volume		str. 403-17
Language		slo
Abstract		Exocytosis, part of which is the merger of the vesicle and the plasma membrane, is characteristic for eukaryotic cells, which engage this process in a myriad of cell functions. For a long time it was believed that exocytosis was predominantly regulated by proteins, a view referred to as 'proteocentric'. Only recently it was shown that many oflipids, previously considered as passive cell membrane components, also play vital roles in regulation of exocytosis. Among others, such lipids are phosphatidylinositol-4,5-biphosphate, diacylglycerol, polyunsaturated fatty acids, sphingosine and cholesterol. Much like proteins, lipids act at various points in the process and influence exocytosis in various ways. The goal of this article is to highlight the role of lipids in exocytosis.
Descriptors		EXOCYTOSIS MEMBRANE FUSION MEMBRANE LIPIDS PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE DIGLYCERIDES FATTY ACIDS, UNSATURATED CHOLESTEROL SPHINGOSINE MEMBRANE PROTEINS BOTULISM OCULOCEREBRORENAL SYNDROME NIEMANN-PICK DISEASE