Author/Editor     Štunf, Špela; Hvala, Anastazija; Vidovič-Valentinčič, Nataša; Kraut, Aleksandra; Hawlina, M
Title     Ultrastructure of the anterior lens capsule and epithelium in cataracts associated with uveitis
Type     članek
Source     Ophthalmic Res
Vol. and No.     Letnik 48, št. 1
Publication year     2012
Volume     str. 12-21
Language     eng
Abstract     Aims: To study the ultrastructure of the anterior lens capsule and epithelium, and capsular thickness in uveitic cataracts. Methods: Capsulorhexis samples from 20 uveitic cataracts were compared to 20 nuclear cataracts using the semi- and ultra-thin techniques. Results: Extensive epithelial and capsular-epithelial border changes and epithelial-mesenchymal transition in some fibrotic capsules were found only in the uveitic group. All these changes were observed predominately in white uveitic cataracts. Mild and moderate ultrastructural changes were seen in both groups. Surface deposition of amorphous material was also found only in uveitic cataracts. Capsular thickness was not different between the two groups. Conclusions: Uveitic capsules showed more extensive and different ultrastructural changes that probably occurred because of inflammation in the eye and epithelial-mesenchymal transition. These changes might be an additional reason for altered behavior of the lens capsule at capsulorhexis.
Descriptors     CATARACT
UVEITIS
LENS CAPSULE, CRYSTALLINE
MICROSCOPY, ELECTRON